Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p028 | Pregnancy | WCRB2014

Targeting placental trophoblast leukemia inhibitory factor with a unique inhibitor: a novel treatment strategy for ectopic pregnancy

Winship Amy , Trishnan Tara , Menkhorst Ellen , Horne Andrew W , Brown Jeremy K , Zhang Jian-Guo , Nicola Nicos , Tong Stephen , Dimitriadis Eva

Introduction: Ectopic pregnancy is unique to humans and a leading cause of maternal morbidity/mortality however the etiology remains unknown. Leukemia inhibitory factor (LIF) has roles in extravillous-trophoblast adhesion/invasion and is expressed in ectopic pregnancy. We hypothesised that LIF facilitates blastocyst adhesion/invasion in the fallopian tube (FT), contributing to ectopic pregnancy. LIF blockade could serve as a treatment strategy.Methods: W...